{
  "_comment": "Interpreted from an AncestryDNA V2.0 raw export (~677k SNPs). A genealogy array is not a clinical test: it reads a tiny fraction of the genome, misses most clinically relevant mutations, and miscalls individual positions at a low but non-zero rate. Confidence flags are per-marker. Edit freely; the page renders whatever it finds here.",
  "source": "AncestryDNA V2.0 raw export",
  "snpsRead": 677000,
  "analyzed": "2026-08",
  "confidence": {
    "high": {
      "label": "Well established",
      "note": "Large, repeatedly replicated effect. Safe to take at face value."
    },
    "moderate": {
      "label": "Moderate",
      "note": "Real but small effect, or fewer replications."
    },
    "low": {
      "label": "Low: curiosity",
      "note": "Behavioral-genetics territory. Entertainment grade."
    },
    "unconfirmed": {
      "label": "Needs confirming",
      "note": "This position is error-prone on arrays. Do not act on it without clinical sequencing."
    },
    "absent": {
      "label": "Not on this chip",
      "note": "The array does not carry the marker, so no call is possible."
    }
  },
  "audit": {
    "title": "Where I don't trust this file",
    "body": "A genotyping chip is not a sequencer. It reads a fixed list of positions, gets a small share of them wrong, and never tells me which ones. Two results below are flagged for exactly that reason. rs6025, the Factor V Leiden position, is strand-ambiguous on arrays and throws false positives often enough that a carrier call on its own means very little. CYP2D6 is not reliably callable on this platform at all, so it comes back absent rather than clear, which is a gap and not a clean result. Everything else here passed silently, and that is the part worth remembering: I have no way to tell a correct call from a wrong one unless something else in the file happens to disagree with it. If a result here ever matters, it needs a real clinical test, not this.",
    "markers": [
      "rs6025"
    ]
  },
  "gaps": [
    {
      "gene": "APOE",
      "detail": "rs7412 read as CC, but rs429358 is absent from the chip. Both are needed to determine ε2/ε3/ε4 status, so the Alzheimer's-associated genotype cannot be called at all."
    },
    {
      "gene": "CYP2D6",
      "detail": "The key markers are not on this array. CYP2D6 affects a large share of common drugs (some antidepressants, opioids, beta-blockers), so this is a real gap rather than a clean result."
    },
    {
      "gene": "ADA (rs73598374)",
      "detail": "Absent. This is the marker most often cited for sleep depth and efficiency, so the sleep panel below is thinner than it looks."
    }
  ],
  "categories": [
    {
      "id": "traits",
      "title": "Traits",
      "blurb": "The part a consumer chip is actually good at. These are single well-studied switches with big effects, so they are the results I trust most in this file.",
      "markers": [
        {
          "gene": "ACTN3",
          "rsid": "rs1815739",
          "genotype": "CC",
          "system": "muscle",
          "confidence": "high",
          "headline": "Sprinter genotype",
          "detail": "Produces functional alpha-actinin-3 in fast-twitch muscle: the version over-represented in power and sprint athletes."
        },
        {
          "gene": "CYP1A2",
          "rsid": "rs762551",
          "genotype": "AA",
          "system": "liver",
          "confidence": "high",
          "headline": "Fast caffeine metaboliser",
          "detail": "Caffeine clears quickly, so it is less likely to interfere with sleep than for a slow metaboliser."
        },
        {
          "gene": "MCM6 / LCT",
          "rsid": "rs4988235",
          "genotype": "AA",
          "system": "gut",
          "confidence": "high",
          "headline": "Lactase persistent",
          "detail": "Digests dairy fine as an adult. Consistent with European ancestry."
        },
        {
          "gene": "ABCC11",
          "rsid": "rs17822931",
          "genotype": "CC",
          "system": "gut",
          "confidence": "high",
          "headline": "Wet earwax, typical body-odour profile",
          "detail": "The dry-earwax and low-odour variant is predominantly East Asian."
        },
        {
          "gene": "TAS2R38",
          "rsid": "diplotype",
          "genotype": "Heterozygous",
          "system": "gut",
          "confidence": "high",
          "headline": "Moderate bitter taster",
          "detail": "Perceives bitterness in raw brassicas (Brussels sprouts, kale) moderately rather than intensely."
        },
        {
          "gene": "COMT",
          "rsid": "rs4680",
          "genotype": "AA (Met/Met)",
          "system": "brain",
          "confidence": "low",
          "headline": "The so-called \"worrier\" genotype",
          "detail": "Slower dopamine breakdown in the prefrontal cortex: often better baseline working memory, sometimes more stress sensitivity under pressure. Behavioral genetics here is weak, so hold it lightly."
        },
        {
          "gene": "–",
          "rsid": "rs10427255",
          "genotype": "TT",
          "system": "brain",
          "confidence": "moderate",
          "headline": "Photic sneeze reflex",
          "detail": "Associated with sneezing on stepping into bright sunlight. Another one that is directly checkable."
        }
      ]
    },
    {
      "id": "athletic",
      "title": "Athletic & recovery",
      "blurb": "How I am built for training. A hybrid engine on a slightly stiff frame, which is roughly what the Training section above shows me doing anyway.",
      "markers": [
        {
          "gene": "ACTN3",
          "rsid": "rs1815739",
          "genotype": "CC",
          "system": "muscle",
          "confidence": "high",
          "headline": "Power and explosiveness",
          "detail": "The fast-twitch allele. Favors sled pushes, carries and short accelerations."
        },
        {
          "gene": "PPARGC1A",
          "rsid": "rs8192678",
          "genotype": "TC",
          "system": "muscle",
          "confidence": "moderate",
          "headline": "Decent mitochondrial capacity",
          "detail": "Leans toward the endurance side, so the profile is mixed rather than pure fast-twitch."
        },
        {
          "gene": "PPARA",
          "rsid": "rs4253778",
          "genotype": "CG",
          "system": "muscle",
          "confidence": "moderate",
          "headline": "Endurance-leaning substrate use",
          "detail": "Together with PPARGC1A this is the hybrid signal: the build a sled-push-plus-run event rewards."
        },
        {
          "gene": "COL5A1",
          "rsid": "rs12722",
          "genotype": "TT",
          "system": "muscle",
          "confidence": "moderate",
          "headline": "Stiffer connective tissue",
          "detail": "Skews toward the less-flexible end and somewhat higher soft-tissue and tendon injury susceptibility."
        },
        {
          "gene": "COL1A1",
          "rsid": "rs1800012",
          "genotype": "CC",
          "system": "muscle",
          "confidence": "moderate",
          "headline": "Same direction as COL5A1",
          "detail": "Practical read: warmups, Achilles and knee prehab, and gradual load progression matter more than average as volume climbs."
        },
        {
          "gene": "MCT1",
          "rsid": "rs1049434",
          "genotype": "TT",
          "system": "muscle",
          "confidence": "moderate",
          "headline": "Reasonable lactate clearance",
          "detail": "Associated with better recovery between high-intensity efforts."
        }
      ]
    },
    {
      "id": "pharmaco",
      "title": "Pharmacogenomics",
      "blurb": "The one category my doctor could actually use. It says which common drugs my liver may clear faster or slower than average, so it changes dosing rather than diagnosis. Worth mentioning if any of these ever get prescribed to me.",
      "markers": [
        {
          "gene": "SLCO1B1",
          "rsid": "rs4149056",
          "genotype": "TC",
          "system": "liver",
          "confidence": "high",
          "flag": true,
          "headline": "One reduced-function copy: statin muscle pain risk",
          "detail": "Associated with higher risk of statin-induced myopathy, especially with simvastatin. Of everything in this file, this is the single most clinically useful flag: it can steer drug choice and dose."
        },
        {
          "gene": "CYP2C19",
          "rsid": "rs4244285",
          "genotype": "AG",
          "system": "liver",
          "confidence": "high",
          "headline": "Intermediate metaboliser",
          "detail": "One *2 loss-of-function copy, with *17 absent. Points toward intermediate metabolism of clopidogrel (Plavix) and some antidepressants and PPIs."
        },
        {
          "gene": "CYP2C9 / VKORC1",
          "rsid": "panel",
          "genotype": "Typical",
          "system": "liver",
          "confidence": "moderate",
          "headline": "Normal warfarin sensitivity",
          "detail": "Only relevant if warfarin ever comes up, and dosing is guided by blood testing anyway."
        },
        {
          "gene": "CYP2D6",
          "rsid": "–",
          "genotype": "Not called",
          "system": "liver",
          "confidence": "absent",
          "headline": "Not covered by this array",
          "detail": "Affects a large share of common drugs. A real gap, not a clean result."
        }
      ]
    },
    {
      "id": "metabolism",
      "title": "Metabolism & nutrition",
      "blurb": "How I handle food and nutrients. Two of these point at a blood test I should just run instead of inferring it from a chip.",
      "markers": [
        {
          "gene": "FUT2",
          "rsid": "rs602662 / rs601338",
          "genotype": "AA / AA",
          "system": "gut",
          "confidence": "high",
          "headline": "Non-secretor",
          "detail": "Two consequences at once: non-secretors tend to run lower on vitamin B12, and they are strongly resistant to the dominant strains of norovirus. The cruise-ship stomach bug mostly passes you by."
        },
        {
          "gene": "GC + CYP2R1",
          "rsid": "rs7041 / rs2282679 / rs10741657",
          "genotype": "AC / TG / AG",
          "system": "blood",
          "confidence": "moderate",
          "flag": true,
          "headline": "Tendency toward lower circulating vitamin D",
          "detail": "A mix of lower-vitamin-D-associated variants. In an Ohio winter this is worth measuring rather than inferring: ask for a 25-OH vitamin D test."
        },
        {
          "gene": "APOA2",
          "rsid": "rs5082",
          "genotype": "AA",
          "system": "metabolic",
          "confidence": "low",
          "headline": "Stronger BMI response to saturated fat",
          "detail": "Loosely: possibly more sensitive to high-saturated-fat diets than average. Modest effect."
        },
        {
          "gene": "BCMO1",
          "rsid": "rs7501331",
          "genotype": "TC",
          "system": "gut",
          "confidence": "moderate",
          "headline": "Reduced beta-carotene conversion",
          "detail": "Somewhat less efficient at converting plant beta-carotene into active vitamin A. Only matters if relying heavily on plant sources; preformed vitamin A from animal foods bypasses it."
        },
        {
          "gene": "MTHFR",
          "rsid": "rs1801133 / rs1801131",
          "genotype": "GG / TG",
          "system": "blood",
          "confidence": "high",
          "headline": "Typical folate metabolism",
          "detail": "C677T is normal with no reduced enzyme function; one copy of A1298C. MTHFR is massively over-hyped online. This is unremarkable, which is the reassuring outcome."
        },
        {
          "gene": "FTO",
          "rsid": "rs9939609",
          "genotype": "AT",
          "system": "metabolic",
          "confidence": "moderate",
          "headline": "One copy of the common appetite allele",
          "detail": "Population-level effect is small and comprehensively swamped by diet and activity."
        }
      ]
    },
    {
      "id": "neuro",
      "title": "Sleep, mood & neuro",
      "blurb": "The weakest section here, and I read it as entertainment. Mood and sleep genetics are tiny effects stacked on tiny effects, and none of it beats just measuring how I actually sleep.",
      "markers": [
        {
          "gene": "CLOCK",
          "rsid": "rs1801260",
          "genotype": "AG",
          "system": "brain",
          "confidence": "low",
          "headline": "No strong chronotype signal",
          "detail": "Intermediate: neither morning lark nor night owl."
        },
        {
          "gene": "NPSR1",
          "rsid": "rs324981",
          "genotype": "AT",
          "system": "brain",
          "confidence": "low",
          "headline": "Mixed sleep-need indicators",
          "detail": "Nothing decisive in either direction."
        },
        {
          "gene": "BDNF",
          "rsid": "rs6265",
          "genotype": "CC",
          "system": "brain",
          "confidence": "moderate",
          "headline": "The common \"efficient\" allele",
          "detail": "Associated with typical memory and stress-response function."
        },
        {
          "gene": "OXTR",
          "rsid": "rs53576",
          "genotype": "GG",
          "system": "brain",
          "confidence": "low",
          "headline": "Higher-empathy end of the literature",
          "detail": "Findings of this kind are weak and should not be over-read."
        },
        {
          "gene": "ADA",
          "rsid": "rs73598374",
          "genotype": "Not called",
          "system": "brain",
          "confidence": "absent",
          "headline": "Absent from the chip",
          "detail": "The marker most often cited for sleep depth and efficiency is not on this array."
        }
      ]
    },
    {
      "id": "health",
      "title": "Health-associated",
      "blurb": "Risk nudges, not verdicts. Every one of these needs a real clinical test before it means anything. I am including them mostly to show how little a chip like this can settle on its own.",
      "markers": [
        {
          "gene": "HFE",
          "rsid": "rs1800562 / rs1799945",
          "genotype": "GG / CC",
          "system": "liver",
          "confidence": "high",
          "headline": "No haemochromatosis risk variant",
          "detail": "Both C282Y and H63D read wild-type. These are two of the better-validated SNPs on the chip, so this is genuinely good to see."
        },
        {
          "gene": "CFTR",
          "rsid": "rs113993960",
          "genotype": "No ΔF508",
          "system": "lungs",
          "confidence": "high",
          "headline": "Not a carrier at the most common CF mutation",
          "detail": "Covers ΔF508 only; CFTR has hundreds of other mutations this array does not read."
        },
        {
          "gene": "HBB",
          "rsid": "rs334",
          "genotype": "TT",
          "system": "blood",
          "confidence": "high",
          "headline": "No sickle allele",
          "detail": "Wild-type at the sickle-cell position."
        },
        {
          "gene": "TCF7L2",
          "rsid": "rs7903146",
          "genotype": "TC",
          "system": "metabolic",
          "confidence": "moderate",
          "headline": "One copy of the most-replicated type-2 diabetes allele",
          "detail": "A modest risk nudge, not a verdict. Fasting glucose and A1c, both in the bloodwork section, are what actually matter."
        },
        {
          "gene": "9p21",
          "rsid": "rs1333049",
          "genotype": "GC",
          "system": "heart",
          "confidence": "moderate",
          "headline": "One copy of a common coronary-artery variant",
          "detail": "Common and modest. Blood pressure, lipids and fitness matter far more, and all three are tracked above."
        },
        {
          "gene": "CDKAL1",
          "rsid": "panel",
          "genotype": "Risk allele present",
          "system": "metabolic",
          "confidence": "moderate",
          "headline": "Another modest type-2 diabetes nudge",
          "detail": "Same category as TCF7L2: small, common, outweighed by measured metabolic markers."
        },
        {
          "gene": "F5 (Factor V Leiden)",
          "rsid": "rs6025",
          "genotype": "TC",
          "system": "blood",
          "confidence": "unconfirmed",
          "flag": true,
          "headline": "Reads as a carrier, but this position is notoriously unreliable",
          "detail": "rs6025 is strand-ambiguous on arrays and false positives are common. Treat as unconfirmed, not alarming. If clotting risk ever matters (surgery, long flights, family history) this is a clean single-gene test to run properly."
        },
        {
          "gene": "F2 (prothrombin)",
          "rsid": "rs1799963",
          "genotype": "Normal",
          "system": "blood",
          "confidence": "moderate",
          "headline": "Normal clotting genotype",
          "detail": "No prothrombin G20210A variant detected."
        },
        {
          "gene": "APOE",
          "rsid": "rs7412 / rs429358",
          "genotype": "Cannot determine",
          "system": "brain",
          "confidence": "absent",
          "headline": "The chapter people most want read is missing",
          "detail": "rs7412 reads CC but rs429358 is absent, and both are needed to call ε2/ε3/ε4. No APOE status can be given from this file."
        }
      ]
    }
  ]
}